Lancet Seminar: Liver cirrhosis

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This Seminar focuses on the diagnosis, complications, and management of cirrhosis, and new clinical and scientific developments. The following topics are covered in the article:

• Epidemiology
• Causes of cirrhosis
• Clinical presentation
• Imaging of cirrhosis
• Liver biopsy
• Natural history and prognosis
• Treatment and reversibility of cirrhosis
• Complications of cirrhosis
• Hepatocellular carcinoma
• Liver transplantation
• Recent advances and future directions
o Molecular pathology of hepatic fibrosis and cirrhosis
o Genetic predisposition for cirrhosis
o Feasibility of pharmacological reversal of cirrhosis
o Non-invasive markers of fibrogenesis and fibrolysis
o Pharmacological and cellular reversal of hepatic fibrosis and cirrhosis
• Conclusions
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