Heart review: Medical treatment of Marfan syndrome

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Heart has featured a review discussing the management of patients with Marfan syndrome. The review highlights the epidemiology, genetics and pathophysiology, and the evidence to support various strategies of treatment, including treatment with beta-blockers, calcium channel blockers, angiotensin converting enzyme inhibitors, aldosterone receptor antagonists, nitrates and drugs that decrease homocysteinaemia.

Marfan syndrome is an autosomal dominant disorder with clinical features including tall stature, arachnodactyly, joint hypermobility, skeletal abnormalities, lens subluxation and mitral valve prolapse.
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